I use Rogaine occasionally together with technique from (Link removed) Very satisfied.

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Falceros - Moderator

My classification (1-10):
(My current regime is 1,2,3,5,6)

1 - Finasteride: 9 (7 years)
2 - Minoxidil: 8 (5 years)
3 - Provillus (natural): 7 (1 year)
4 - Revivogen: 6 (1 year)
5 - Nizoral 2%: 6 (5 years)
6 - Ecophane (multivinaminic): 6 (3 years)
7 - Folligen: 5 (1 year)
8 - Aminexil (Dercos): 5 (6 months)
9 - Proxiphen-N: 4 (over priced!) (1 year)

Hey Guys. I just wanted to say a word about dutasteride dosing.

As you all are aware there have been no studies of dutasteride as it relates to hairloss so the question remains: How much and how often do we need to take it? Well the medical community has a general rule: "the smallest dose for the shortest time" to achieve the desired effect. Our desired effect of course is the blockage of DHT without gynecomastia(man boobs) and other estrogenic effects. According to the pivotal study, the pharmacokinetics and pharmacodynamics of dutasteride were evaluated in 36 healthy male subjects aged between 24 and 87 years following administration of a single 5-mg dose of dutasteride. In this single-dose study, dutasteride half-life increased with age (approximately 170 hours in men aged 20 to 49 years, approximately 260 hours in men aged 50 to 69 years, and approximately 300 hours in men older than 70 years). Of 2,167 men treated with dutasteride in the 3 pivotal studies, 60% were age 65 and over and 15% were age 75 and over. No overall differences in safety or efficacy were observed between these patients and younger patients. What all of this means to US (Balding dudes) is that if you are between age 20-49 and you take ONE avodart gel cap, it will take 7 Days for Half of the dose to be eliminated from your body....So you decide for yourself. Personally I take one 0.5mg soft-gel capsule every 3 days and have Never had estrogenic effects of anykind and my sex drive is "Strong Like Bull" Hope this helps.

Yes I've studied Pharmacology Extensively

I started with Propecia at .5mg a day to get my system used to the drug. I did this for a few days. Now I take .5mg twice a day to equal 1mg.
I may go back to .5mg a day because I read something that Mercks test of .5mg a day was pretty close to 1mg a day. $$$$$$$

I would be careful with Dust. I think your body needs some DHT??.

Blowdry,
Binding of DHT to the hair follicle results in gradual miniaturization of the hair and eventual hair loss. DHT is primarily responsible for the physical changes that occur during male sexual Maturation and is thought to be proportionally correlated to sex drive as well as erectile capabilities in men. In addition, DHT has been associated with benign prostate hypertrophy (BPH) and prostate cancer. So your body probably needs "some" DHT although it seems to do more harm than good....I don't think any studies have been done to determine just how much we actually need for sex drive, it's probably a minute amount though.

But I think Dust gets rid of both types of DHT. And one is used for brain function I think.

Copied from the Las Vegas meeting notes:

Both finasteride and dutasteride inhibit the development of the type 2 alpha reductase that plays a critical role in the creation of the hair loss causing hormone DHT, only dutasteride also effectively inhibits the development of the type 1 alpha reductase that also plays a role in creating DHT.

According to Dr. Bernie Nusbaum, who presented an update on Dutasteride therapy at the meeting, dutasteride is three times more potent than finateride at inhibiting the type 2 enzyme and 300 times more potent than finasteride in inhibiting the type 1 enzyme.

Based on a randomized, placebo controlled study of 416 male hair loss sufferers, dutasteride improved hair growth in these men more rapidly and to a greater degree than finasteride.

However, dutasteride was shown to remain in the body far longer than finasteride after being discontinued. Dutasteride was also found to reduce sperm counts more dramatically than finasteride along with a higher incidence of decreased libido (13%).

Of additional concern, dutasteride, unlike finasteride, reduces the type 1 enzyme which is found in the brain – unlike the type 2 enzyme which is not present in the brain. Apparently it is not clear at this time what role the type 1 enzyme may or may not play in the functioning of the brain. Thus dutasteride could potentially have yet unknown side effects due to reducing the type 2 enzyme in the brain.

Robert so are you saying that avodart is better than propecia since it blocks 100% of serum dht??

mrkneed,

I don't know if Robert will respond as I haven't seen him for awhile - he floats in and out once in awhile.

But from the report above copied by blowdry, written by Pat our Publisher, yes, Dudasteride is a more potent drug and potentially more effecitve - however, it has not been fully clinically tested and there are most likely higher risks of side effects.

What scares me is that type 1 enzymes are also inhibited and these are found in the brain. The question is...what implication does that have and are there potential concerns for long term use?

I guess until it's been fully tested, we won't have the answer to that question.

Falc

quote:

Originally posted by mrkneed:
Robert so are you saying that avodart is better than propecia since it blocks 100% of serum dht??

No, I'm not saying that Avodart is better than Propecia at all. In my post I was explaining what the report from the Las Vegas meeting notes have further confirmed: extensive research has proven that Avodart is a much more potent medication and inhibits much more type 2 alpha-reductase as well as type 1.

It is because of this that I choose to take Avodart. However, I have never suggested that anyone else to take it because it is not FDA-approved for the treatment of male-pattern baldness and because of the unknown role of type 1 alpha-reductase has on the brain, as Falceros pointed out.

Anyone considering adding Avodart to their regimen should research the drug as much as possible and talk to their doctor about it first.

I really mean that last part, guys: TALK TO YOUR DOCTOR.

-Robert

I'm almost 11 months into proscar with nothing to report. I don't see any difference in my hair loss, or maintenance. It seems as though the sides of the scalp are continuing to drop, especially around the crown, which is widening.

I'm also experiencing what I believe are side effects as it relates to it's intended purpose -- prostate. I've read that these include burning sensations after urination, which I've had for quite some time.

2 years on Propecia, minoxidil 5% and nizoral. No hair loss and thicker hair. But 100 euros / month is too much... I think I will buy generics in the future

I also tried Revivogen and proxiphen-n. But minoxidil & propecia are much better

Peter88, If your current meds have worked for you so far, non-generic that is, I wouldn't want to see you change anything and just stick to that!!

hi guys, I been taking propecia, I only lost few hair from the sides nw2 say. Will propecia work for my crown the sides or not? frontal hair receding hairline from one side.

Will propecia work for the front?

plz help .

thankyou

My regimen:


Propecia- 1mg everyday
Rogaine-5% Foam twice everyday on crown/hairline
Biotin 1000mg - Everyday, good for hair health
Vitamin 400 i.u. - Everyday
Revita - Almost everyday, but way too expensive
Nizoral 1% - Dont know where to find the 2%


Iam keeping my fingers crossed as i have been on this regimen for 5 weeks. I am in a major, major shed right now that started right after I started Propecia, which is prollly a good thing as this may indicate the meds are working!!!

Iam currently using Nism newhair biofactors with succes

I've been taking Propecia (1 mg daily) for about 7 or 8 years. I started losing my hair behind the hairline and further back around the age of 23-24. It was thinning drastically. Got on Propecia and after about 1 year I had significant regrowth and thickening back up of my hair. Recently i am thinning again (I'm now 32) and at times feel I am getting back to as bad or worse than I was before. I am considering adding Rogaine to the regimen and already added Saw Palmetto (figured couldn't hurt). I am going to go back to my derm and discuss options. Guess I should be happy for the 7-8 years I got on Propecia, but no one ever said "Oh by the way, it will stop working or lose its effectiveness after some period of years and you will be back to where you were years ago but have dumped this drug in your system the whole time." Who knows would I have even started? Anyway, any thoughts would be appreciated.

Maybe try Dut Thats why I do Mon wed fri because Im afraid if I start too high the same thing may happen . Bloodwork says lower is just as good

Kal-el...The reason Propecia stopped its effectiveness is not because the drug stopped working, but rather because you caught up to the drug...In some cases (this includes me), when you have hair loss on both sides of the family, your hair loss can be so severe not even a combination of the big 3 (Nizoral, Rogaine and Fin) can stop it...The big 3 can slow it down though, but eventually there will come a point when there is nothing you can do...At 32 years old, at least you got to enjoy your twenties and are at an age now where hair loss is prevelant (30% of men at 32 have significant hair loss)...From hearing your story, I hope you had a fun twenties...Consider yourself a succes story, because in cases where the Fin stops working, that means that you were supposed to lookse your hair 10 years ago....Congrats man, you beat it for 10 years...Im 23 years old, and have recently re-started on Fin...Ive got some ground to make up (i look very thin in front and have a tiny bald spot in back)...I can only hope for the results you had...Again, I hope you made the most of your 20s, and congratulations...